WebThis episode is about the pathophysiology on crystallopathies. The cellular pathways involved unify multiple concepts and multiple branches of medicine, from toxicology to cardiology to rheumatology and oncology. WebApr 1, 2024 · Crystallopathies represent major health burdens, especially in the Western World. Identification of novel disease genes of nephrolithiasis and nephrocalcinosis. Apart from testing for the prevalence of known Mendelian disorders, next-generation sequencing techniques have also advanced the field of gene identification in crystallopathies.
PMA and crystal‐induced neutrophil extracellular trap formation ...
Crystallopathies can be associated with four main kinds of crystalline structures: liquid non-aggregating crystal solutions, amorphous nano-scale solid particles, crystalline micro-scale solid particles, and polycrystalline larger solid structures. They can be composed of various minerals, metabolites, proteins, … See more Crystallopathy is a harmful state or disease associated with the formation and aggregation of crystals in tissues or cavities, or in other words, a heterogeneous group of diseases caused by intrinsic or … See more Local supersaturation is a common trigger of crystallization, and when the nucleus of the crystalline structure is formed, crystals can self-perpetuate and cause more crystallization and aggregation. Main mechanisms by which the formed crystals and aggregates … See more In principle, crystal formation can happen anywhere in the body. Well-known places are excretory organs where concentrations get high easily, like in the biliary and urinary tracts, … See more The most straightforward treatment of crystallopathies would be dissolving the crystals. Crystal dissolvents have been under research, for … See more WebNov 4, 2015 · These data imply that RIPK1, RIPK3, and MLKL could represent molecular targets in gout or other crystallopathies. Introduction Neutrophil extracellular trap (NET) formation was first described to enhance bacterial killing via the release of histones, ROS, and proteases 1 , 2 , but also contributes to autoinflammatory and autoimmune disorders … green acres smithland
Frontiers Binding of Macrophage Receptor MARCO, LDL, and …
WebJul 1, 2024 · The basic distribution of crystallopathies in nephrology is as follows: renovascular crystallopathy (type 1), tubular crystallopathy (type 2), and finally urolithiasis (type 3) (tab. 1). Nowadays ... WebNov 14, 2024 · In crystallopathies, crystals or crystalline particles of environmental and metabolic origin deposit within tissues, induce inflammation, injury and cell death and eventually lead to organ-failure. The NLRP3-inflammasome is involved in mediating crystalline particles-induced inflammation, but pathways leading to cell death are still … flower mart barbados