[email protected] didates for further experimental characterization. The basic assumption underlying structure-based drug de-sign is that a good ligand molecule should bind tightly to its target. WebbThis patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
University of Michigan
WebbWang is also on the board of Ascentage Pharma Group International Co., Ltd., Oncopia Therapeutics, Inc., Rogel Cancer Center: University of Michigan and Ascentage International Ltd. Shao Meng Wang previously held the position of Editor-in-Chief at Journal of Medicinal Chemistry, Professor at the University of Michigan, Assistant Professor at Georgetown … Webb11 nov. 2024 · Based on our previous STAT3 SH2 domain inhibitor CJ-887 (compound 1) (Chen et al., 2010a), we have performed extensive optimization, as summarized in Figure 1 A, to obtain potent and cell-permeable STAT3 inhibitors.First, we designed compound 2 by cyclization of the amino group with the phenyl group to form an indole, which binds to … chiropractor north branch mn
Shaomeng Wang - DBLP
WebbAntitumor activity of APG-2449 was evaluated in mice bearing subcutaneous tumors derived from H3122 NSCLC cells carrying EML4-ALK fusion gene (A; treated for 3 weeks, n = 7 per treatment group; T/C values were assessed on Day 21), KARPAS-299 cells carrying NPM-ALK fusion gene (B; treated for 3 weeks, n = 7 per treatment group; T/C values were … Webb13 dec. 2024 · Professors Gunda Georg and Shaomeng Wang served as joint Editors-in-Chief of the Journal of Medicinal Chemistry from 2011 to 2024, succeeding Professor … WebbWe first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain. Employing ligands for cereblon/Cullin 4A E3 ligase and SI-109, we obtained a series of … chiropractor no insurance near me